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October 23, 2025Clinical & Translational OncologyOpen Access

The effects of tetrahydrocannabinol and cannabidiol on sleep in cancer patients

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Authors

ARApoorva ReddyJHJohn M. HamptonSPSusan Park

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Overview

Analysis of sleep improvement in cancer patients, suggesting higher doses of CBD may enhance sleep quality.

Key Points

  • Sleep disturbance scores improved by 1.87 points with high CBD doses, highlighting its therapeutic value.
  • Lower CBD doses showed a 29–35% lower likelihood of achieving significant sleep improvements for cancer patients.
  • Multivariable logistic and linear regression models were used to analyze reported symptom responses from 1962 cancer patients enrolled in a medical cannabis program.
  • Higher CBD doses are associated with clinically meaningful improvements, indicating potential benefits for physicians recommending cannabinoids.

Cite This Study

Reddy et al. (2025) studied this question.

synapsesocial.com/papers/68fa32a40df2e6cd2f742243https://doi.org/10.1007/s12094-025-04069-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Indications of Cannabinoids for the Palliation of Cancer-Associated Symptoms: A Systematic Review and Meta-Analysis2025
  2. 2Comparative Effects of THC and CBD on Chemotherapy-Induced Peripheral Neuropathy: Insights from a Large Real-World Self-Reported Dataset2025
  3. 3Therapeutic Use of Cannabis and Cannabinoids2025 · 50 citations
  4. 4Impact of Medical Cannabis on the Quality of Life of Cancer Patients: A Critical Review2025
  5. 5UK Medical Cannabis Registry: A clinical outcomes analysis for insomnia2025