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August 1, 2025Current Oncology ReportsOpen Access

Indications of Cannabinoids for the Palliation of Cancer-Associated Symptoms: A Systematic Review and Meta-Analysis

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Authors

ICIoana Creangă-MurariuIRIoana-Irina RezușRKR. Karami

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Overview

Systematic review finds cannabinoids reduce pain and anxiety in cancer patients, indicating potential benefits but also significant risks.

Key Points

  • Cannabinoids demonstrated significant reductions in cancer-related pain by -1.22 and anxiety by -1.30 compared to baseline values.
  • The review included 98 studies examining cannabinoids against standard care and placebo for symptom management.
  • Cannabinoids showed a tendency to improve appetite and nausea but did not significantly affect constipation, depression, or overall quality of life.
  • THC-predominant formulations posed a high risk of psychiatric and neurological side effects, requiring careful patient selection.

Cite This Study

Creangă-Murariu et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfd03https://doi.org/10.1007/s11912-025-01695-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cannabinoids for the prevention of chemotherapy-induced nausea and vomiting in oncological therapy: a systematic review2025
  2. 2Therapeutic Use of Cannabis and Cannabinoids2025 · 50 citations
  3. 3Are cannabinoids with cancer immunotherapy contributing to early death? A call for caution and further study2025
  4. 4Impact of Medical Cannabis on the Quality of Life of Cancer Patients: A Critical Review2025
  5. 5Therapeutic use of cannabis and cannabinoids: benefits and risks.2025