Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 23, 2025Science ProgressOpen Access

METTL3: A dual regulator of oral tissue regeneration and malignancy with therapeutic implications for stem cell therapy and chemoresistance

View Full Paper
Ask AI
Bookmark
Share

Authors

CLChang LiuYWYan WangYLYuanhong Liang

Discussion

Loading...

Member takes

Overview

This narrative review shows METTL3's dual role in oral tissue regeneration and malignancy, indicating its potential in stem cell therapy and overcoming chemoresistance.

Key Points

  • Oral tissue regeneration and malignancy are significantly influenced by METTL3's regulatory functions, highlighting its dual role.
  • It stabilizes mRNA transcripts like GDF6 and enhances dentinogenesis, pointing to its regenerative potential.
  • Dysregulated METTL3 is linked to osteogenesis impairment in periodontal cells, worsening disease severity.
  • Targeting METTL3 with drugs like Oxymatrine may provide new avenues for therapies in both regenerative dentistry and oncology.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68f9d6583f378872224924f2https://doi.org/10.1177/00368504251389718
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Targeting METTL3 disrupts oncogenic transcriptional programs and activates immune and apoptotic pathways in Acute Myeloid Leukemia2025
  2. 2Targeting O-GlcNAcylated METTL3 impedes MDS/AML progression via diminishing SRSF1 m6A modification2025 · 1 citations
  3. 3Recent advances in small molecules targeting the METTL32025 · 3 citations
  4. 4METTL13 Promotes Pre-Leukemic Transformation and the Development of Pediatric Leukemia2025
  5. 5The methyltransferase METTL3 promotes the progression of breast cancer cells via regulating EGF m6A modification2025 · 3 citations