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October 23, 2025Open Access

TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins

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Authors

XLXianghua LiBLBen Lehner

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Overview

Analysis demonstrates gene expression regulation by transcription factors, suggesting potential for therapeutic intervention.

Key Points

  • The analysis shows that DNA-binding proteins can be mapped functionally and allosterically.
  • Transcription factors regulate gene expression, affecting multiple pathways in disease.
  • Observational analysis reveals that allosteric sites influence DNA-binding activities in specific proteins.
  • This approach highlights the therapeutic potential of targeting transcription factors in drug development.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68f9a0eb8ea8f2f37ee94d93https://doi.org/10.1101/2025.10.20.683418
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Scalable transcription factor mapping uncovers the regulatory dynamics of natural and synthetic transcription factors in human T cell states2025
  2. 2Predicting the DNA binding specificity of transcription factor mutants using family-level biophysically interpretable machine learning2025
  3. 3DNA Conformational Flexibility Descriptors Improve Transcription Factor Binding Prediction Across the Protein Families2025
  4. 4Integrating Protein and DNA Embeddings for Improving Genome-Wide Transcription Factor Binding Site Prediction2025
  5. 5Protocol for multiplexed transcription factor activity detection using optimized barcoded reporters and an automated computational pipeline2025