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September 11, 2025STAR ProtocolsOpen Access

Protocol for multiplexed transcription factor activity detection using optimized barcoded reporters and an automated computational pipeline

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Authors

MTMax TrauernichtVFVinícius H. Franceschini-SantosHYHatice Yücel

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Implication

Protocol outlines multiplexed transcription factor activity detection using barcoded reporters, indicating high-throughput potential.

Key Points

  • This protocol enables efficient detection of transcription factor activity through a barcoded reporter system.
  • Authors detail methodology for library transfection and RNA processing, alongside a computational analysis pipeline.
  • The computational pipeline supports differential transcription factor activity analysis in cultured cells effectively.
  • High-throughput profiling may enhance understanding of regulatory networks and cellular responses.

Cite This Study

Trauernicht et al. (2025) studied this question.

synapsesocial.com/papers/68d418c5713b0b5dfea63ebchttps://doi.org/10.1016/j.xpro.2025.104066
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