Systematic integration of DNA flexibility descriptors improves binding predictions in transcription factors, suggesting a critical role in gene regulation.
Key Points
The study reveals that DNA flexibility plays a key role in transcription factor binding predictions.
Flexibility-augmented predictive models outperform traditional sequence and shape models in accuracy.
Distinct 'flexibility hotspots' were identified within binding sites that significantly influence binding affinity.
Findings underscore the importance of DNA conformational dynamics in enhancing the understanding of gene regulatory networks.