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August 25, 2025Frontiers in MedicineOpen Access

Identification and validation for biomarkers associated with mitochondrial metabolism in chronic obstructive pulmonary disease

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Authors

WWWenjun WangLWLanxiang WuCOChen Ouyang

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Overview

Observational analysis identified biomarkers APRT and LCAT in COPD, suggesting potential for early diagnosis and treatment.

Key Points

  • APRT and LCAT emerged as significant biomarkers for chronic obstructive pulmonary disease, revealing potential for early diagnosis and therapeutic strategies.
  • The analysis highlighted a significant decrease in mRNA and protein expression of APRT and LCAT in the lung tissues of COPD patients.
  • Assessment utilized bioinformatics methods including differential expression analysis and machine learning to identify candidate genes and biomarkers.
  • Functional enrichment revealed pathways like ribosome co-enriched with these biomarkers, indicating their role in disease mechanisms.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68af79ab7567bf4f94ff1ac9https://doi.org/10.3389/fmed.2025.1612390
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