Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 13, 2025Archive of Ukrainian OphthalmologyOpen Access

Changes in the endothelial functional state on the background of diabetic retinopathy (experimental modelling)

View Full Paper
Ask AI
Bookmark
Share

Authors

ODO.Yu. Denysiuk

Discussion

Loading...

Member takes

Overview

Experimental modeling shows changes in endothelial dysfunction in diabetic retinopathy, suggesting serious impacts on microvascular health.

Key Points

  • Endothelial dysfunction was marked by increases in endothelin-1 and VCAM, alongside a decrease in t-PA levels.
  • Significant changes in endothelial function were evident from day 60 in a rat model of type 2 diabetes.
  • A streptozotocin-induced model demonstrated critical insights into the pathogenesis of diabetes complications.
  • The findings highlight the endothelial state's importance in predicting diabetic retinopathy outcomes.

Cite This Study

O.Yu. Denysiuk (2025) studied this question.

synapsesocial.com/papers/68ec51df42911f61ef8b218ehttps://doi.org/10.22141/2309-8147.13.2.2025.412
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelial function can be modulated by acute hyperglycemia2025 · 6 citations
  2. 2<b>Investigating Late-Stage Diabetic Retinopathy: A Long-Term Analysis of Vascular Changes in the Streptozotocin-Induced Mouse Model</b>2025
  3. 3Investigating Late-Stage Diabetic Retinopathy: A Long-term Analysis of Vascular Changes in the Streptozotocin-Induced Mouse Model2025
  4. 4Breakthroughs in diabetic retinopathy diagnosis and treatment using preclinical research models: current progress and future directions2025
  5. 5Endothelial to mesenchymal transition: a central mechanism in diabetes-induced vascular pathology2025