Endothelial to mesenchymal transition: a central mechanism in diabetes-induced vascular pathology

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Review reveals endothelial to mesenchymal transition impacts vascular health in diabetes, suggesting new therapeutic approaches.

Endothelial to mesenchymal transition significantly contributes to vascular dysfunction in diabetes, leading to complications.
This review discusses signaling pathways such as TGF-β, Notch, and Wnt, and their influence on EndMT.
Preclinical and human studies underscore the clinical relevance of EndMT in complications like nephropathy and retinopathy.
Anti-EndMT therapies show promise in targeting diabetic vascular diseases, indicating potential for novel treatments.

Vu et al. (2025) studied this question.

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