Microenvironment of Solid Tumors

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This review discusses insights on tumor microenvironment interactions and stromal cell diversity, indicating new co-treatment strategies.

Tumor microenvironment interactions significantly influence tumor progression and cancer cell survival.
Solid tumors like pancreatic ductal adenocarcinoma are mechanically stiff, impacting treatment efficacy.
Recent advancements include classifying stromal cells through single-cell sequencing for better therapeutic strategies.
Exhausted immune cells in the tumor microenvironment highlight challenges in combating aggressive cancers.

Korneenko et al. (2025) studied this question.

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