Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 12, 2025European Heart Journal - Quality of Care and Clinical OutcomesOpen Access

Using SCORE2 with a risk chart or online calculator: Impact on model performance, treatment eligibility and cardiovascular disease prevention

View Full Paper
Ask AI
Bookmark
Share

Authors

SHSteven H J HagemanSKStephen KaptogeMGMari Nordbø Gynnild

Discussion

Loading...

Member takes

Overview

Observational analysis finds that SCORE2 risk charts yield higher treatment eligibility, implying online calculator offers better discrimination.

Key Points

  • Risk assessment with SCORE2 risk charts overestimates cardiovascular disease risk and treatment eligibility.
  • In the low risk region, median 10-year risk predicted by risk charts was 4.0%, compared to 3.7% from the online calculator.
  • Discrimination was better with the online calculator, showing a C-statistic increase of +0.010 in the low risk region.
  • SCORE2 risk charts resulted in a higher treatment eligibility rate of 6.3% in the low risk region versus 4.0% with the calculator.

Cite This Study

Hageman et al. (2025) studied this question.

synapsesocial.com/papers/68ebe3d6becc64ad52fdadf2https://doi.org/10.1093/ehjqcco/qcaf122
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1SCORE2 charts assign a different risk category than the underlying model in a large portion of Polish primary care patients2025
  2. 2CHARIOT: Development and Internal Validation of a Cardiovascular Health Assessment and Risk-based Intervention Optimisation Tool2025 · 1 citations
  3. 3Predictive significance of the calcium index in assessing cardiovascular risk2025
  4. 4Comparison of Globorisk, SCORE2, and PREVENT in the Stratification of Cardiovascular Risk and its Relationship with End‐Organ Damage Among Adults With Arterial Hypertension2025 · 2 citations
  5. 5External Validation and Head-to-Head Comparison of Cuore and Score2 Cardiovascular Risk Scores in an Italian Primary Care-Administrative Cohort2026