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September 20, 2025Open Access

CHARIOT: Development and Internal Validation of a Cardiovascular Health Assessment and Risk-based Intervention Optimisation Tool

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Authors

APAlexander PateBJBowen JiangYHYixin Huang

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Overview

Retrospective cohort study developed a risk prediction model for cardiovascular disease, indicating effective interventions.

Key Points

  • The model predicts 10-year cardiovascular disease risk under various interventions including statins and weight loss.
  • Under internal validation, the model demonstrates high discrimination with c-statistics of 0.874 for females and 0.859 for males.
  • Calibration was maintained across diverse groups, showing consistent performance through protected characteristics and regional classifications.
  • Evaluation of the model suggests it is ready for clinical use, pending further piloting and validation in practice.

Cite This Study

Pate et al. (2025) studied this question.

synapsesocial.com/papers/68d438ff713b0b5dfea7879ahttps://doi.org/10.1101/2025.09.18.25336064
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