Why the study?
How do the CUORE and SCORE2 cardiovascular risk scores compare for 10-year prediction of first fatal or non-fatal myocardial infarction or stroke in an Italian primary care cohort?
Population
38,101 adults in an Italian primary care cohort (ATS Milan, baseline 2007-2009)
Comparison
CUORE cardiovascular risk score vs SCORE2 cardiovascular risk score
Design
Cohort
Follow-up
10 years
Key result
CUORE (AUC 0.730-0.741) and SCORE2 (AUC 0.713-0.720) provided moderate discrimination for 10-year risk of first fatal or non-fatal myocardial infarction or stroke in an Italian primary care cohort.
Authors
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Both scores enable moderate discrimination and robust stratification in Italian primary care; leaves open optimal local recalibration and endpoint definitions before threshold-guided decisions.
Cohort (n=38,101)
How do the CUORE and SCORE2 cardiovascular risk scores compare for 10-year prediction of first fatal or non-fatal myocardial infarction or stroke in an Italian primary care cohort?
Effect estimate: AUC 0.730-0.741 (CUORE); AUC 0.713-0.720 (SCORE2)
Both CUORE and SCORE2 provide moderate discrimination for 10-year cardiovascular risk in an Italian primary care cohort, though absolute risk estimates are highly sensitive to administrative endpoint definitions and recalibration strategies.
Milanese et al. (2026) conducted a cohort in Cardiovascular risk (n=38,101). CUORE and SCORE2 risk scores was evaluated on First fatal or non-fatal myocardial infarction or stroke (AUC 0.730-0.741 (CUORE); AUC 0.713-0.720 (SCORE2)). CUORE (AUC 0.730-0.741) and SCORE2 (AUC 0.713-0.720) provided moderate discrimination for 10-year risk of first fatal or non-fatal myocardial infarction or stroke in an Italian primary care cohort.