October 11, 2025Open Access

Hypothesis-generating analysis of mutational signatures in childhood B-cell acute lymphoblastic leukemia in relation to socio-demographic, genetic, and environmental factors: A report from the Children's Oncology Group

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SBS2 and SBS13 mutational signatures are linked to patient sex and socio-economic status.
Males have reduced burdens of SBS2 and SBS13 compared to females, highlighting sex-related differences.
Hispanic/Latine cases show significant enrichment of SBS2 and SBS13, indicating potential genetic disparities.
Clock-like signatures are associated with parental and patient age, suggesting age-related exposure influences.

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Analysis shows associations between mutational signatures, socio-demographic factors, and environmental exposures in B-cell ALL.

Clark et al. (2025) studied this question.

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