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December 8, 2025BloodOpen Access

DNA methylation markers assessed at birth are associated with future development of pediatric acute lymphoblastic leukemia

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Authors

ENEric Nickels

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Overview

Analysis reveals early DNA methylation markers associated with future pediatric acute lymphoblastic leukemia, highlighting potential modifiable risks.

Key Points

  • Altering DNA methylation may indicate future development of pediatric acute lymphoblastic leukemia.
  • Significant discovery of differentially methylated regions linked to leukemia risk emphasizes preventive strategies.
  • Epigenome-wide association study conducted on neonatal dried blood spots reveals critical methylation changes.
  • Findings suggest that DNA methylation patterns could act as early markers for pediatric leukemia prevention.

Cite This Study

Eric Nickels (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e0dbhttps://doi.org/10.1182/blood-2025-331
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic relevance of epigenetic regulation of drug pharmacology and myeloid genes in pediatric AML2025
  2. 2Molecular reactivity in maternal pregnancy blood and neonatal dried blood spots is associated with risk of pediatric acute lymphoblastic leukemia2025
  3. 3Hypermethylation of the ribosomal DNA coding sequence and disordered transcription factor binding as hallmarks of acute myeloid leukemia2025
  4. 4Epigenetic markers expand genetic risk estimation in acute myeloid leukemia2026
  5. 5DNA methylation instability as a biomarker to predict resistance or progression to advanced disease Phase following tyrosine kinase inhibitor therapy in chronic myeloid leukemia2025