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September 5, 2025Frontiers in PharmacologyOpen Access

Efficacy and safety of oral anticoagulants in the treatment of chronic kidney disease with atrial fibrillation or venous thromboembolism: a systematic review and meta-analysis

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Authors

QYQinan YinXZXingyue ZhengXNXiaoqing Ni

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Overview

Systematic review shows DOACs improve outcomes in CKD patients with atrial fibrillation or venous thromboembolism, suggesting better safety than warfarin.

Key Points

  • DOACs significantly lower the risk of hemorrhagic stroke in CKD patients with AF compared to warfarin.
  • The meta-analysis included 15 randomized controlled trials involving over 16,000 participants, ensuring robust findings.
  • Both DOACs and warfarin had similar risks of major bleeding in patients with kidney dysfunction on either therapy.
  • Results indicate that DOACs exhibit superior efficacy in reducing specific bleeding risks while showing comparable effectiveness in preventing VTE.

Cite This Study

Yin et al. (2025) studied this question.

synapsesocial.com/papers/68c238d2b210217d647793d1https://doi.org/10.3389/fphar.2025.1615284
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative efficacy and safety of warfarin and direct oral anticoagulants in patients with end-stage renal disease and atrial fibrillation2026 · 1 citations
  2. 2The Renal Impact of Direct Oral Anticoagulants versus Vitamin K Antagonists in Patients with Atrial Fibrillation: A Systematic Review and Meta-analysis2026
  3. 3Effectiveness and safety of direct oral anticoagulants versus vitamin K antagonists in atrial fibrillation patients with liver disease: a systematic review and meta-analysis2025
  4. 4New aspects of anticoagulant therapy in atrial fibrillation in patients with renal dysfunction2020
  5. 5Comparative Efficacy and Safety of Novel Oral Anticoagulants in Atrial Fibrillation with Chronic Kidney Disease: A Systematic Review, Meta-Regression, and Network Meta-Analysis2025