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October 10, 2025Open Access

Obesity concurrent with gestational diabetes mellitus dysregulates mitochondria-endoplasmic reticulum contacts in human placenta

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Authors

RWR. WangJLJianying LiuQLQian Li

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Overview

Study reveals that obesity with gestational diabetes disrupts mitochondrial and ER interactions, indicating placental dysfunction.

Key Points

  • Obesity concurrent with gestational diabetes leads to increased apoptosis in placental tissues.
  • Reduced trophoblast cell count and disorganized cell arrangement noted in placenta from affected mothers.
  • Elevated oxidative stress and ER stress markers were found in placentas of women with obesity and GDM.
  • Increased formation of mitochondrial-endoplasmic reticulum contacts correlated with placental dysfunction.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68e861b07ef2f04ca37e4ab7https://doi.org/10.21203/rs.3.rs-7658198/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dysregulation of placental mitochondrial structure dynamics and clearance in maternal obesity and gestational diabetes2025
  2. 2Effects of Gestational Metabolic Abnormalities on Placenta2025
  3. 3Placental dysfunction in maternal obesity is a key mechanism of fetal programming of metabolic syndrome2025
  4. 4Gestational Diabetes and Obesity: Immediate and Late Sequelae for Offspring2025
  5. 5Gene Expression Profile of Placenta and Adipose Tissue in Women with Gestational Diabetes Mellitus2025