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October 10, 2025ImmunologyOpen Access

LAG‐3+ Regulatory T Cells Suppress Effector Function of T Cells and Allow Their Proliferation Into Regulatory T Cells

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Authors

ADAvijit DuttaSMShi‐Chuen MiawTCTse‐Ching Chen

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Overview

Regulatory T cells inhibit effector functions in CD4+ T cells, suggesting a pathway for immune tolerance.

Key Points

  • Regulatory T cells suppress the effector function of cognate antigen-specific CD4+ T cells, enhancing tolerance.
  • In vitro, LAG-3+ T cells inhibit IFN-γ responses and show increased immune checkpoint expression, indicating functional modulation.
  • Adoptive transfer of LAG-3+ T cells rescues mice from lethal autoimmune pulmonitis in a dose-dependent manner.
  • Genomic studies show retained proliferative capacity in suppressed T cells, despite reduced oxidative metabolism.

Cite This Study

Dutta et al. (2025) studied this question.

synapsesocial.com/papers/68e8619c7ef2f04ca37e419fhttps://doi.org/10.1111/imm.70046
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