August 20, 2025Open Access

Regulatory T cells sabotage antitumor γδ T cells by creating IL-2-deficient environments

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Depletion of regulatory T cells enhances antitumor responses in γδ T cells, suggesting IL-2 may be key for therapy effectiveness.

Depleting regulatory T cells boosts IFNγ-producing γδ T cells, improving tumor control in breast cancer models.
Neutralizing IL-2 while depleting regulatory T cells stops IFNγ+ γδ T-cell responses, highlighting IL-2's importance.
In vivo experiments confirmed that IL-2 receptor agonists can overcome regulatory T cell suppression in γδ T cells.
Addressing regulatory T cell suppression could enhance the effectiveness of γδ T-cell immunotherapies.

Silva‐Santos et al. (2025) studied this question.

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August 20, 2025Open Access

View Full Paper

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Authors

Depletion of regulatory T cells enhances antitumor responses in γδ T cells, suggesting IL-2 may be key for therapy effectiveness.

Depleting regulatory T cells boosts IFNγ-producing γδ T cells, improving tumor control in breast cancer models.
Neutralizing IL-2 while depleting regulatory T cells stops IFNγ+ γδ T-cell responses, highlighting IL-2's importance.
In vivo experiments confirmed that IL-2 receptor agonists can overcome regulatory T cell suppression in γδ T cells.
Addressing regulatory T cell suppression could enhance the effectiveness of γδ T-cell immunotherapies.

Silva‐Santos et al. (2025) studied this question.

View Full Paper

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Bookmark