Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Open Access

High throughput profiling of the B cell repertoire identifies systematic changes in the repertoire of individuals with Crohn's disease

View Full Paper
Ask AI
Bookmark
Share

Authors

AMAya K.H. MahdyZTZahra TaheriUniversity of TehranMHMarte Lie Høivik

Discussion

Loading...

Member takes

Implication

High throughput profiling reveals reduced diversity and increased clonality in Crohn's disease patients, suggesting antigen-driven expansions.

Key Points

  • Individuals with Crohn's disease show reduced B cell repertoire diversity and increased clonality, pointing to disease-related changes.
  • Significant alterations in specific immunoglobulin clonotypes were observed, including expansions of IgA2 and IgG2 among Crohn's disease patients.
  • The somatic hypermutation rate in the immunoglobulin heavy chain gene was significantly reduced for specific B cell types in Crohn's disease.
  • These findings highlight the importance of the B cell repertoire in identifying potential antigenic exposures related to Crohn's disease.

Cite This Study

Mahdy et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d64789d74https://doi.org/10.1101/2025.09.01.673486
View Full Paper
Ask AI
Bookmark
Share