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October 8, 2025Global Cardiology Science and PracticeOpen Access

Mapping the Proteomic Landscape of Congenital Aortic Valve Stenosis Using a Notch1;Gata5 Mutant Mouse Model

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Authors

ARAnupama RaoTCTalita Zahin ChoudhuryAVAirines Valezquez

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Overview

This study identifies molecular changes in congenital aortic valve stenosis, indicating potential biomarkers and therapeutic targets.

Key Points

  • Significant alterations in 364 proteins were detected, with about 9% linked to extracellular matrix organization.
  • Elevated integrin proteins suggest dysregulation of TGF-β signaling, indicating impaired valve remodeling in congenital aortic valve stenosis.
  • Network analysis identifies CTNNB1 as a potential upstream regulator, linking to Wnt signaling pathway activation.
  • These findings highlight early molecular changes in congenital AVS and suggest candidates for biomarker development and intervention.

Cite This Study

Rao et al. (2025) studied this question.

synapsesocial.com/papers/68e5c1c76950a706b22b5f4chttps://doi.org/10.21542/gcsp.2025.hvbte.20
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