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August 24, 2025Open Access

Spatial transcriptomic profiling of the human aortic valve reveals cellular sex differences near sites of calcification

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Authors

TBTalia BaddourSanford Consortium for Regenerative MedicineVNVan K. NinhUC San Diego Health SystemRGRayyan GorashiUniversity of California, San Diego

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Implication

Spatial transcriptomics reveals differing gene expression patterns in valvular interstitial cells and macrophages by sex, suggesting distinct mechanisms of aortic valve calcification.

Key Points

  • Gene expression in aortic valves shows significant male-dependent patterns, particularly in the Activator Protein 1 complex.
  • Histological analyses reveal increased calcification area in diseased male valves compared to females, with unique cellular interactions influencing fibrosis.
  • Single cell sequencing highlights spatial organization differences in valvular interstitial cells between sexes, impacting cell behavior and disease progression.
  • Communication between macrophages and valvular interstitial cells indicates a female-specific mechanism driving fibrosis near calcification sites.

Cite This Study

Baddour et al. (2025) studied this question.

synapsesocial.com/papers/68af799f7567bf4f94ff1392https://doi.org/10.1101/2025.08.20.671175
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