Abstract Fri137: Loss of Hsp90β Enhances Mitochondrial Cristae Density and Preserves Mitochondrial Structure Under Stress

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Cardiac-specific Hsp90β knockout improves mitochondrial integrity and calcium uptake capacity, suggesting new chaperone roles.

Loss of hsp90β leads to enhanced mitochondrial structure and cristae density, positively impacting cell resilience.
Mitochondria from hsp90β knockout mice exhibit improved calcium uptake before any rupture, indicating better functionality.
Transmission electron microscopy revealed more preserved mitochondrial structures in hsp90β knockout hearts after stress induction.
Findings suggest that hsp90β does not act as a pro-survival chaperone in the heart as previously thought.

Roberts et al. (2025) studied this question.

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