October 9, 2025Circulation Research

Abstract Fri019: Targeting ER/SR HAX-1/Hsp90 Interaction to Enhance Cardiomyocyte Contractility and Survival upon Stress

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Authors

SSSujoita SenUniversity of Delaware RRRichard E. RobertsUniversity of Nottingham HWHalley WisnerUniversity of Delaware

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Implication

Experimental analysis shows improved contractility and cell viability in cardiomyocytes under stress, suggesting HSP90/HAX-1 modulation enhances cardioprotection.

Key Points

Modulating the HSP90/HAX-1 interaction significantly improved cardiomyocyte contractility and survival under stress.
Application of interfering peptides enhanced calcium kinetics in human-induced pluripotent stem cell-derived cardiomyocytes.
Targeting ER/SR locations of the HSP90/HAX-1 interaction provided the most cardioprotective effects during induced stress conditions.
Utilization of AAV6 vectors to deliver peptides indicated potential for enhanced therapeutic application in cardiac disease.

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Sen et al. (2025) studied this question.

synapsesocial.com/papers/68e80eb363e2e2f707877d8b https://doi.org/10.1161/res.137.suppl_1.fri019

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Implication

Experimental analysis shows improved contractility and cell viability in cardiomyocytes under stress, suggesting HSP90/HAX-1 modulation enhances cardioprotection.

Abstract Fri019: Targeting ER/SR HAX-1/Hsp90 Interaction to Enhance Cardiomyocyte Contractility and Survival upon Stress

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract Fri019: Targeting ER/SR HAX-1/Hsp90 Interaction to Enhance Cardiomyocyte Contractility and Survival upon Stress

Discussion

Member takes

Implication

Key Points

Cite This Study

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