September 5, 2025JACC Basic to Translational ScienceOpen Access

Novel Peptide Therapeutics Targeting the L-Type Calcium Channel Prevent Hypertrophic Cardiomyopathy by Decreasing Mitochondrial Energetics

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Authors

TETeagan ErThe University of Western Australia DRDaniel C. ReinkeThe University of Western Australia AFAlice J. FrancisThe University of Western Australia

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Implication

In vivo treatment improved contractile function and reduced hypertrophic cardiomyopathy in mice, suggesting peptide therapeutics target L-type calcium channels.

Key Points

In vivo treatment with peptide variants effectively prevented hypertrophic cardiomyopathy in mouse models.
Three out of four peptide variants demonstrated high affinity binding to the beta subunit of the L-type calcium channel.
Modifying mitochondrial energetics through L-type calcium channel targeting showed potential for future therapies.
These findings suggest a novel approach to treating hypertrophic cardiomyopathy by using peptide therapeutics.

Cite This Study

Er et al. (2025) studied this question.

synapsesocial.com/papers/68c2384fb210217d64776bca https://doi.org/10.1016/j.jacbts.2025.04.006

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Implication

In vivo treatment improved contractile function and reduced hypertrophic cardiomyopathy in mice, suggesting peptide therapeutics target L-type calcium channels.

Novel Peptide Therapeutics Targeting the L-Type Calcium Channel Prevent Hypertrophic Cardiomyopathy by Decreasing Mitochondrial Energetics

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Member takes

Implication

Key Points

Cite This Study

Novel Peptide Therapeutics Targeting the L-Type Calcium Channel Prevent Hypertrophic Cardiomyopathy by Decreasing Mitochondrial Energetics

Discussion

Member takes

Implication

Key Points

Cite This Study

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