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October 9, 2025Endocrinology Diabetes & MetabolismOpen Access

Remnant Cholesterol and Cardiovascular Risk in Adults With Type 1 Diabetes: A Nested Case–Control Study

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Authors

FSFernando Sebastián‐VallesIHIñigo Hernando‐AldayLLLuis Eduardo Lander Lobariñas

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Overview

Nested case–control study finds elevated remnant cholesterol raises cardiovascular disease risk, suggesting crucial lipid management.

Key Points

  • Elevated remnant cholesterol is independently linked to a higher risk of cardiovascular disease in adults with type 1 diabetes.
  • Individuals with remnant cholesterol levels in the highest quartile showed an odds ratio of 4.50 for cardiovascular disease.
  • The analysis was conducted using a nested case–control design within a multicentre cohort of adults with type 1 diabetes.
  • These findings underline the necessity for targeted lipid-lowering strategies to achieve LDL-C treatment goals in individuals with type 1 diabetes.

Cite This Study

Sebastián‐Valles et al. (2025) studied this question.

synapsesocial.com/papers/68e7ba40ccde5f1021f64ca0https://doi.org/10.1002/edm2.70114
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Remnant Cholesterol: From Pathophysiology to Clinical Implications in Type 1 Diabetes2025
  2. 2Factors Involved in the Progression of Preclinical Atherosclerosis in People with Type 1 Diabetes2025
  3. 3Treatment of Dyslipidemia in Patients with Type 1 Diabetes Mellitus: A Review of Current Evidence and Knowledge Gaps2025
  4. 4P47 - Cardiovascular risk and lipid markers in people with type 1 diabetes and diabetic ketoacidosis2025
  5. 5Risk and protective factors for coronary atherosclerosis and myocardial dysfunction in individuals with long-duration type 1 diabetes2025