Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 20, 2025DiabetologiaOpen Access

Risk and protective factors for coronary atherosclerosis and myocardial dysfunction in individuals with long-duration type 1 diabetes

View Full Paper
Ask AI
Bookmark
Share

Authors

MYMarc Gregory YuHSHetal ShahSJSurya Jangolla

Discussion

Loading...

Member takes

Overview

Cross-sectional analysis reveals high cardiovascular disease prevalence in long-duration type 1 diabetes, suggesting inflammation and glycaemic levels play significant roles.

Key Points

  • Participants exhibited a high burden of coronary atherosclerosis, with 40% having cardiovascular disease despite good management.
  • Among 1038 individuals, HbA1c and osteopontin were significantly associated with cardiovascular disease risk in the non-DKD group.
  • Using multivariable regression, various inflammatory biomarkers were assessed, indicating their relevance in coronary artery health.
  • The findings highlight the need for better management of glycaemia and inflammation in individuals with long-duration type 1 diabetes.

Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/68af35efcf1dd9ea359ea61dhttps://doi.org/10.1007/s00125-025-06521-4
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Factors Involved in the Progression of Preclinical Atherosclerosis in People with Type 1 Diabetes2025
  2. 2P47 - Cardiovascular risk and lipid markers in people with type 1 diabetes and diabetic ketoacidosis2025
  3. 3Coronary Artery Calcification in Type 1 Diabetes After 10-Year Ketogenic Diet2025
  4. 4Glycemic Control, Cardiac Autoimmunity, and Long-Term Risk of Cardiovascular Disease in Type 1 Diabetes Mellitus2019 · 125 citations
  5. 5Time-Cumulative Residual Cardiovascular Risk in Patients with Coronary Heart Disease and Diabetes: A 10-Year Follow-Up Study from a Large-Scale Population Cohort and an Independent Clinical Validation Cohort2026