Abstract Thu147: The Complex Role of ROR2 in Fibroblast Activation and Tissue Mechanics

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Experimental study reveals ROR2 impacts fibroblast migration and wound healing in right ventricular failure, suggesting complex cellular dynamics.

ROR2 enhances wound healing in neonatal rat ventricular fibroblasts while decreasing proliferation in human fibroblasts.
CellProfiler analysis demonstrated that ROR2 impact on cell migration is linked to weakened cell junctions in both NRVFs and HuFBs.
ROR2 knockdown resulted in increased tissue stiffness and compaction, indicating its critical role in cardiac fibroblast function.
Study suggests that ROR2 may have age and species-dependent effects that could influence therapeutic strategies for right ventricular failure.

Hartman et al. (2025) studied this question.

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Experimental study reveals ROR2 impacts fibroblast migration and wound healing in right ventricular failure, suggesting complex cellular dynamics.