Abstract Thu127: Reductive stress alters high density lipoprotein (HDL) functionality and induces atheroma

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Reductive stress impairs HDL functionality and promotes atheroma development in cardiovascular disease patients.
CVD patients with reductive stress exhibited lower total HDL cholesterol and reduced Apo A1 content.
Foam cell formation was significantly increased in macrophages treated with reductive stress-modified HDL.
In vivo studies show vascular remodeling and increased pulse wave velocity in mice subjected to reductive stress.

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Experimental analysis shows that reductive stress alters HDL function in CVD patients, suggesting it exacerbates atherosclerosis.

Rajkumar et al. (2025) studied this question.

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