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September 5, 2025Medicinal Chemistry

Design, Synthesis, Biological Evaluation, and In Silico Studies of Tetrazole Derivatives as Potential Cytotoxic Agents

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Authors

MPMahalakshmi C. S. ParepalliRGRajitha Galla

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Overview

Experimental evaluations reveal that tetrazole derivatives induce apoptosis and inhibit EGFR in human cancer cells, suggesting new therapeutic avenues.

Key Points

  • Compound 6d demonstrated significant cytotoxicity against A549 cells, inducing apoptosis and cell cycle arrest.
  • MTT assay showed compound 6d had an IC50 of 2.74 μM, outperforming doxorubicin's IC50 of 3.87 μM.
  • Molecular docking indicated that compound 6l has strong binding affinity towards EGFR, acting as a potential inhibitor.
  • Favorable ADME properties exhibited by the synthesized tetrazole derivatives support their potential as effective cancer therapies.

Cite This Study

Parepalli et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477a362https://doi.org/10.2174/0115734064389466250805052834
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