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December 8, 2025Blood

Outcomes after relapse for adolescent and young adult patients with ALL: Results from the Children's oncology group

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Authors

ADAlice DangXXXinxin XuNWNaomi Winick

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Overview

Analysis of relapse outcomes in adolescents and young adults with ALL shows age effects and highlights risk factors.

Key Points

  • Overall survival for AYAs with ALL after relapse was 27.7%, indicating they face significant challenges.
  • In multivariate analysis, minimal residual disease and ethnicity did not significantly affect survival post-relapse.
  • Cohort analysis drew from twelve clinical trials for B-ALL and T-ALL, focusing on relapse risk factors.
  • Findings suggest incorporating age in risk stratification may improve understanding and treatment of AYAs.

Cite This Study

Dang et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc76https://doi.org/10.1182/blood-2025-548
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  3. 3Real-world data of adolescents and young adults with acute lymphoblastic leukemia treated with a modified GMALL protocol in India: Treatment outcomes and challenges2025
  4. 4Role of race and ethnicity in survival among children/young adults with relapsed ALL: a Children's Oncology Group report2025
  5. 5Disparate post-relapse survival outcomes by race/ethnicity for children with B-cell acute lymphoblastic leukemia: An analysis from the recall-1 study2025