October 8, 2025Annals of HematologyOpen Access

Clinical profile and treatment outcomes in paediatric and adult acute promyelocytic leukemia: experience from a tertiary care centre in Northern India

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Discussion

Retrospective cohort study reveals high early mortality and significant infection risk in APL patients, indicating urgent need for tailored care.

Induction mortality reached 24.5%, mainly due to hemorrhage and infections linked to acute promyelocytic leukemia.
Survival rates showed a 2-year overall survival of 75.9%, with lower rates in high-risk patients compared to low-risk ones.
Early diagnosis is critical, as median diagnosis delay was 18 days, exacerbating complications in acute promyelocytic leukemia patients.
Challenges such as infection and differentiation syndrome significantly affect treatment outcomes in APL, particularly in resource-limited settings.

Mamlekar et al. (2025) studied this question.

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Retrospective cohort study reveals high early mortality and significant infection risk in APL patients, indicating urgent need for tailored care.