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December 8, 2025BloodOpen Access

Clinical, cytogenetic and molecular predictors of early mortality in acute promyelocytic leukemia (APL): Real-world analysis

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Real-world analysis finds that FLT3 mutations and coagulopathy predict early mortality in acute promyelocytic leukemia.

Early mortality significantly correlates with FLT3 mutations and coagulopathy in acute promyelocytic leukemia.
Among analyzed acute promyelocytic leukemia patients, 12.5% experienced early mortality primarily due to intracranial hemorrhage.
Observational analysis included 64 acute promyelocytic leukemia patients diagnosed at Yale New Haven Hospital from 2013 to 2024.
Highlights the need for larger studies to clarify the impact of genetic abnormalities on acute promyelocytic leukemia outcomes.

Shallis et al. (2025) studied this question.

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