Outcomes of treatment of childhood acute promyelocytic leukemia according to the APL 2003/2008 protocols in Russia and Belarus

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Analysis of survival rates and incidence of acute promyelocytic leukemia in children, highlighting treatment protocol effectiveness.

Five-year overall survival for treated children was 82%, with significant differences between risk groups.
In the low-risk group, five-year overall survival reached 93%, compared to only 63% in the high-risk group.
Children treated according to the APL 2003/2008 protocols showed an 8.7% relapse rate in the low-risk group versus 15% in the high-risk group.
Most treatment-related deaths were due to brain haemorrhage, emphasizing the need for strategies to reduce early mortality.

Aleinikova et al. (2025) studied this question.

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