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October 3, 2025Methods and ProtocolsOpen Access

Effects of Different Centrifugation Parameters on Equilibrium Solubility Measurements

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Authors

RSRita SzolláthVBVivien BárdosMSMarcell Stifter-Mursits

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Overview

This study investigates how centrifugation time and speed affect solubility measurements in drug compounds, indicating optimal methods for accurate bioavailability assessment.

Key Points

  • Pre-sedimented samples provided solubility values more aligned with references, indicating better accuracy.
  • Centrifugation at 5000 rpm for 5 min yielded results closest to reference values, with lower standard deviations.
  • Higher centrifugation speeds and longer durations led to overestimated solubility values, especially for specific compounds.
  • Different solubility measurements were obtained across various pH levels, emphasizing the need for careful parameter selection.

Cite This Study

Szolláth et al. (2025) studied this question.

synapsesocial.com/papers/68e040f7a99c246f578b3a67https://doi.org/10.3390/mps8050116
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