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August 19, 2025The Journal of Physical Chemistry BOpen Access

Solvent Redistribution Method To Determine Solubility and Aggregation: High Throughput, Accuracy, and Sustainability

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Authors

OTOrly B. TarunNDNathan DupertuisDWDavid M. Wilkins

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Overview

This method demonstrates improved solubility detection in the pharmaceutical industry, suggesting reduced CO2 emissions.

Key Points

  • Solvent redistribution method achieves over a thousandfold increase in sustainability while measuring solubility.
  • The detection limit for solubility and aggregation is reduced from ∼1 μM to ∼1 nM, indicating high accuracy.
  • Assessment involves nonlinear light scattering modeling and classical nucleation theory to analyze solute interactions.
  • This method could reduce the pharmaceutical industry's CO2 emissions by ∼3.5%, highlighting its environmental significance.

Cite This Study

Tarun et al. (2025) studied this question.

synapsesocial.com/papers/68af33d5cf1dd9ea359e875ahttps://doi.org/10.1021/acs.jpcb.5c03073
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