September 10, 2025Open Access

A Comparative Study on The Dissolution Enhancement of Poorly Soluble Drugs Using Solid Dispersion Vs. Nanosuspension Techniques

View Full Paper

Ask AI

Bookmark

Authors

NRNikhil Rajnani NKNalini Kurup

Discussion

Member takes

Implication

Experimental comparison shows nanosuspension significantly enhances dissolution in poorly soluble drugs, indicating its superiority over solid dispersion techniques.

Key Points

Nanosuspension achieved a particle size of 210.4 nm, significantly enhancing dissolution rates compared to solid dispersion.
Dissolution studies revealed 96.2% drug release for nanosuspension after 30 minutes, outpacing solid dispersion's 85.4% release.
Solid dispersion showed partial amorphization (42.5% crystallinity), whereas nanosuspension achieved near-complete amorphization (12.8%).
Both formulation methods maintained stability under accelerated conditions, indicating their feasibility for pharmaceutical applications.

Cite This Study

Rajnani et al. (2025) studied this question.

synapsesocial.com/papers/68c243f6b210217d647a9ccc https://doi.org/10.64063/3049-1681.vol.2.issue8.1

View Full Paper

Ask AI

Bookmark

Implication

Experimental comparison shows nanosuspension significantly enhances dissolution in poorly soluble drugs, indicating its superiority over solid dispersion techniques.