Revolutionizing Solid Tumor Surgery with Fibroblast Activation Protein (FAP)-Targeted Imaging Probes for a Fluorescence-Guided Surgery of Pancreatic Cancer

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Novel fluorescent probes enhance surgical detection in pancreatic cancer, suggesting improved outcomes with NIRF-guided surgery.

FAP-targeting fluorescent probes significantly improve tumor visualization in pancreatic cancer surgeries, enhancing surgical precision.
In vivo studies revealed eFAP-24's tumor-to-background ratio of 3.1, demonstrating its potential for effective intraoperative imaging.
The probes showed strong selective uptake in FAP-expressing cells, indicating their effectiveness in targeted imaging and treatment.
These developments support the approach of utilizing NIRF technology in solid tumors with dense stroma, particularly for better surgical outcomes.

Ma et al. (2025) studied this question.

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