A General Strategy to Develop Highly Sensitive FAPα Fluorescent Probes for Invasive Cancer Detection

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Novel design improves sensitivity of fluorescent probes for tumor detection and delineation in carcinomas, indicating clinical potential.

The FAPα-activated fluorescent probe demonstrated enhanced sensitivity in detecting invasive tumors.
FQCy7 showed significant improvement in affinity and sensitivity toward FAPα, aiding in carcinoma studies.
The probe's positive charge strategy increases the accuracy of tumor margin delineation during evaluations.
This innovative approach provides a vital tool for precise cancer detection, potentially impacting treatment outcomes.

Feng et al. (2025) studied this question.

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