October 3, 2025Frontiers in ImmunologyOpen Access

Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury

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Neutrophil heterogeneity reveals four subtypes linked to sepsis-associated acute kidney injury.
Significant increases in pro-inflammatory neutrophils (40.53%) noted in sepsis compared to controls (4.19%).
Multi-omics approach utilized single-cell and bulk RNA sequencing alongside animal and human validation.
Findings highlight molecular drivers like peptidyl arginine deiminase 4, suggesting novel therapeutic targets.

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This analysis identifies neutrophil subtypes and molecular drivers in acute kidney injury, suggesting potential biomarkers for sepsis.

Cheng et al. (2025) studied this question.

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