Uncovering molecular markers of the microvascular endothelial response in sepsis-associated acute kidney injury: a translational study in mice and humans

View Full Paper

Ask AI

Bookmark

The study identifies key markers of endothelial response in sepsis-associated acute kidney injury.
Identified genes like Hp, C3, and MMP8 were upregulated in both mice models and human patients.
Analysis utilized spatially resolved transcriptomics and validated findings through RT-qPCR in kidney tissues.
Increased protein levels suggest widespread endothelial activation in the context of sepsis pathophysiology.

Discussion

No takes yet. Share an insight, caveat, or question.

Translational analysis defined microvascular gene expression and circulating proteins in sepsis, indicating their roles in acute kidney injury.

Aart et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark

Translational analysis defined microvascular gene expression and circulating proteins in sepsis, indicating their roles in acute kidney injury.