August 20, 2025Frontiers in ImmunologyOpen Access

Identification of sepsis biomarkers through glutamine metabolism-mediated immune regulation: a comprehensive analysis employing mendelian randomization, multi-omics integration, and machine learning

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Glutamine metabolism plays a crucial role in the immune response to sepsis, influencing outcomes.
Mendelian randomization analysis linked glutamine degradation to the HLA-DR + NK cell composition in sepsis.
Single-cell RNA sequencing revealed significant variations in immune cell phenotypes between control and sepsis groups.
Predictive models using machine learning achieved high accuracy in identifying biomarkers for sepsis.

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Mendelian randomization uncovers biomarkers in sepsis using multi-omics data, suggesting immune cell roles.

Shi et al. (2025) studied this question.

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