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October 3, 2025Open Access

Decreased Mitochondrial Respiration in Peripheral Mononuclear Blood Cells in Chil-dren and Adolescents with Obesity and Type 2 Diabetes Mellitus

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Authors

MRM RechtsteinerSASamiya Al‐RobaiyHZHans Zischka

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Overview

Study shows decreased mitochondrial respiration in peripheral blood mononuclear cells in youth with obesity, indicating early metabolic issues.

Key Points

  • Data reveal that mitochondrial respiration and Bioenergetic Health Index are significantly lower in adolescents with type 2 diabetes compared to their insulin-resistant peers.
  • In a cohort of 162 participants, glycoATP correlated with higher insulin and HbA1c levels in children suffering from obesity and insulin resistance.
  • Postpubertal adolescents demonstrated significantly lower coupling efficiency in mitochondrial function, emphasizing the impact of obesity on metabolic health.
  • The findings suggest that impaired mitochondrial function may be an early indicator of metabolic impairment in young individuals with obesity.

Cite This Study

Rechtsteiner et al. (2025) studied this question.

synapsesocial.com/papers/68e02f46f0e39f13e7fa2d2chttps://doi.org/10.1101/2025.09.30.25336982
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