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September 23, 2025Frontiers in EndocrinologyOpen Access

Alterations in peripheral CD4+ T cell subsets and their association with metabolic markers in obese children

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Authors

RSReiko SaitoJHJun HirakawaMKMami Kuwamura

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Overview

Prospective study reveals alterations in CD4+ T cell subsets in obese children, indicating immune dysregulation and metabolic associations.

Key Points

  • CD4+ T cell counts and the naïve to memory T cell ratio are lower in obese children compared to non-obese peers.
  • Regulatory T cell levels are higher in obese children, showing a unique immune response distinct from adults.
  • Alterations in T cell subsets correlate with various metabolic markers like insulin and blood glucose levels.
  • Variations in T cell populations depend on the duration of obesity in children, highlighting an evolving immune landscape.

Cite This Study

Saito et al. (2025) studied this question.

synapsesocial.com/papers/68d43ed1713b0b5dfea7dff2https://doi.org/10.3389/fendo.2025.1635379
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