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October 3, 2025

SOX4-Mediated Post-Transcriptional suppression of PTEN via miR-106b~25 Cluster Contributes to Prostate Cancer Aggressiveness.

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Authors

FSFeifei SunLGLin GaoMWMeng Wang

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Overview

This study demonstrates SOX4 downregulates PTEN via miR-106b~25 in prostate cancer, suggesting new therapeutic targets.

Key Points

  • SOX4 high and PTEN low expression correlates with aggressive prostate cancer subtypes with poor prognosis.
  • Mechanistically, SOX4 downregulates PTEN via post-transcriptional modulation by activating miR-106b~25 cluster.
  • Dual targeting of SOX4 and PI3K-AKT signaling can effectively inhibit prostate cancer proliferation and invasion.
  • Findings highlight the importance of molecular risk stratification in guiding precision therapies for prostate cancer.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68e02f2cf0e39f13e7fa1f33https://doi.org/10.1158/1541-7786.mcr-25-0471
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1miR-145-5p and miR-148b-3p Expression Is Inversely Associated with Pten Expression in Prostate Pathologies2025
  2. 2Prognostic Significance of PTEN Loss in Prostate Cancer: A Meta-Analysis of Gleason Grade and Clinical Outcomes2025
  3. 3Integrating Single-Cell and Bulk RNA Sequencing Reveals the Malignant Phenotype of CBX4 in Prostate Cancer2025
  4. 4SOX2 utilizes FOXA1 as a heteromeric transcriptional partner to drive proliferation in therapy-resistant prostate cancer2025 · 2 citations
  5. 5Exploration of oncogenic cooperation between germline variation and somatic mutation in prostate cancer progression2025