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September 5, 2025CancersOpen Access

Prognostic Significance of PTEN Loss in Prostate Cancer: A Meta-Analysis of Gleason Grade and Clinical Outcomes

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Authors

FKFilip KisielDFDougal FergusonCHClaire A. Hart

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Overview

Meta-analysis reveals PTEN loss predicts higher Gleason grades and adverse clinical outcomes in prostate cancer.

Key Points

  • PTEN loss significantly correlates with increased tumour aggressiveness, especially in higher Gleason grades.
  • Increased odds of PTEN loss in Gleason grades 2 and 3 is 2.78, and 6.35 in grades ≥ 4 compared to GG1.
  • This systematic review and meta-analysis of 16 studies assessed over 11,000 patients with prostate cancer.
  • Incorporating PTEN assessment may improve risk stratification for prostate cancer patients facing aggressive disease.

Cite This Study

Kisiel et al. (2025) studied this question.

synapsesocial.com/papers/68c239a3b210217d6477d87chttps://doi.org/10.3390/cancers17172862
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of PTEN Tumor Suppressor Genes in Endometrial Cancer2025 · 3 citations
  2. 2SOX4-Mediated Post-transcriptional Suppression of PTEN via miR-106b∼25 Cluster Contributes to Prostate Cancer Aggressiveness2025 · 1 citations
  3. 3Exploration of oncogenic cooperation between germline variation and somatic mutation in prostate cancer progression2025
  4. 4Population-based Characterization of PTEN Hamartoma Tumor Syndrome2025
  5. 5miR-145-5p and miR-148b-3p Expression Is Inversely Associated with Pten Expression in Prostate Pathologies2025