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October 2, 2025Minerva Endocrinology

Effects of low protein diet supplemented with ketoanalogues on kidney function and nutritional outcomes in a nonagenarian population with advanced chronic kidney disease: a pilot study

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Authors

GAGiuseppe AnnunziataMTMarinelli TeresaMAMelfitano Armando

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Overview

Pilot study finds significant improvements in renal function and nutritional status among elderly patients with chronic kidney disease, indicating potential benefits of low protein diets and ketoanalogues.

Key Points

  • Significant improvement in GFR from 18.04 to 24.30 mL/min was observed after 12 months on a low protein diet supplemented with ketoanalogues.
  • Azotemia levels decreased significantly from 122.38 to 70.19 mg/dL, demonstrating nutritional interventions can enhance kidney function.
  • Predicted risk of end-stage renal disease improved markedly, with KFRE scores dropping from 33.67% to 15.09% at 2 years, indicating effective management of chronic kidney disease.
  • No cardiovascular events or deaths were reported, suggesting that the dietary approach may safely improve outcomes for nonagenarians.

Cite This Study

Annunziata et al. (2025) studied this question.

synapsesocial.com/papers/68de8eaeaa6cec72c69ea914https://doi.org/10.23736/s2724-6507.25.04416-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Kidney Nutrition for Value-Based Care Models: The Role of Low Protein Diets and Keto-Analogue Supplementation to Delay Dialysis2025
  2. 2Low‐protein diet for chronic kidney disease: Evidence, controversies, and practical guidelines2025
  3. 3Combining Ketoacid Analog Supplemented Low-Protein Diets with Sodium-Glucose Cotransporter-2 Inhibitors for Patients with Diabetic Kidney Disease2025
  4. 4Protein restriction in nondialysis chronic kidney disease patients2026
  5. 5Associations of Increased Plant Protein Intake Ratio with Adherence of Low-Protein Diet, Acid-Base Status, and Body Composition in CKD Stage 3–52025