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October 2, 2025Clinical Journal of the American Society of NephrologyOpen Access

Combining Ketoacid Analog Supplemented Low-Protein Diets with Sodium-Glucose Cotransporter-2 Inhibitors for Patients with Diabetic Kidney Disease

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Authors

CYChieh‐Li YenPFPei‐Chun FanCLCheng‐Chia Lee

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Overview

Retrospective cohort study finds lower risks of all-cause and cardiovascular mortality with combined therapy in diabetic kidney disease patients.

Key Points

  • Combination therapy significantly reduced all-cause death risk over three years compared to KA-AA alone.
  • The combination group had lower rates of cardiovascular death, with a hazard ratio of 0.68.
  • This study involved 1729 adult patients with type 2 diabetes and advanced stages of diabetic kidney disease.
  • Results indicate that combining SGLT2 inhibitors with a low-protein diet can improve outcomes in diabetic kidney disease.

Cite This Study

Yen et al. (2025) studied this question.

synapsesocial.com/papers/68de5d9c83cbc991d0a2055dhttps://doi.org/10.2215/cjn.0000000846
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