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September 10, 2025Journal of Internal MedicineOpen Access

Low‐protein diet for chronic kidney disease: Evidence, controversies, and practical guidelines

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Authors

DMDenise MafraIBIsabela de Souza da Costa BrumNBNatália A. Borges

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Overview

Narrative review reveals low-protein diet influences clinical outcomes in chronic kidney disease patients, suggesting balanced protein intake is essential.

Key Points

  • Excessive protein intake is linked to cardiovascular issues and oxidative stress, impacting kidney function.
  • Patients with chronic kidney disease may benefit from a low-protein diet if their individual needs are considered.
  • Overly restrictive protein consumption risks muscle mass loss, negatively affecting clinical outcomes.
  • An individualized approach to protein intake is crucial for managing chronic kidney disease effectively.

Cite This Study

Mafra et al. (2025) studied this question.

synapsesocial.com/papers/68c23e4fb210217d64791f8fhttps://doi.org/10.1111/joim.20117
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protein restriction in nondialysis chronic kidney disease patients2026
  2. 2Protein Intake and Kidney Health: A Literature Review of Healthy Individuals, Athletes and CKD Patients2025
  3. 3Chronic kidney disease and diet2025
  4. 4Effects of low protein diet supplemented with ketoanalogues on kidney function and nutritional outcomes in a nonagenarian population with advanced chronic kidney disease: a pilot study2025
  5. 5Associations of Increased Plant Protein Intake Ratio with Adherence of Low-Protein Diet, Acid-Base Status, and Body Composition in CKD Stage 3–52025