Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 2, 2025Journal of Clinical InvestigationOpen Access

Acetyl-CoA carboxylase-1 inhibition increases regulatory T-Cell metabolism and graft-vs-host disease treatment efficacy via mitochondrial fusion

View Full Paper
Ask AI
Bookmark
Share

Authors

CMCameron McDonald-HymanEAEthan G. AguilarECEwoud B. Compeer

Discussion

Loading...

Member takes

Overview

Inhibition of acetyl-CoA carboxylase-1 enhances regulatory T-cell function, suggesting strategies for optimizing graft-vs-host disease therapies.

Key Points

  • Inhibition of ACC1 significantly increases Treg suppressive function in vitro and in mice with graft-vs-host disease.
  • ACC1 inhibition promotes regulatory T-cell metabolic changes, enhancing fatty acid oxidation and oxidative phosphorylation.
  • Mitochondrial fusion plays a key role in Treg function, as its inhibition reduces the benefits of ACC1 suppression.
  • Expanded human Treg treated with ACC1 inhibitors show improved suppressor function, paralleling murine findings.

Cite This Study

McDonald-Hyman et al. (2025) studied this question.

synapsesocial.com/papers/68de84bb5b556a9128e1ba48https://doi.org/10.1172/jci182480
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Monocarboxylate transporter 1 deficient donor T cells rewire metabolism and ameliorate aGVHD lethality2025
  2. 2Dysfunctional glycolysis-UCP2-fatty acid oxidation promotes CTLA4intFOXP3int regulatory T-cell production in rheumatoid arthritis2025
  3. 3Metabolic adaptions of regulatory T cells in non-lymphoid tissues 25582025
  4. 4Transforming acidic coiled-coil-containing protein 3-mediated lipid metabolism reprogramming impairs CD8+ T-cell cytotoxicity in hepatocellular carcinoma2025 · 14 citations
  5. 5Purin Metabolism Is Crucial for Regulatory T Cell Stability and Function2025